Triethylamine → Phosphoramidic dichloride, bis(2-chloroethyl)-

HRID 649337

반응식

HRID 649337 반응식
[P:1]([Cl:5])(Cl)([Cl:3])=[O:2].[Cl:6][CH2:7][CH2:8][NH:9][CH2:10][CH2:11][Cl:12].C(N(CC)CC)C.Cl.C(N(CC)CC)C>C1COCC1>[Cl:6][CH2:7][CH2:8][N:9]([CH2:10][CH2:11][Cl:12])[P:1]([Cl:5])([Cl:3])=[O:2]

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 9533Bis(2-chloroethyl)amineHCID 11130Triethylamine hydrochlorideHCID 24813Phosphorus oxychloride

생성물 1

HCID 96271Phosphoramidic dichloride, bis(2-chloroethyl)-

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

Phosphorous oxychloride (0.15 mol) in 100 ml. THF are mixed dropwise at 10° C. with bis-chloroethylamine (0.1 mol) in 100 ml. THF and triethylamine (0.15 mol). After ending of the reaction (TLC verification), triethylamine hydrochloride is filtered off and the filtrate, after the addition of 50 ml. toluene, evaporated. The oily residue is immediately further reacted.

후처리

  1. filtrationis filtered off
  2. additionthe filtrate, after the addition of 50 ml
  3. customtoluene, evaporated
  4. customThe oily residue is immediately further reacted

출처 및 근거

ORD 기록
ord-c0af85cf54a442ee855b99cb32b2c48a
출처 데이터셋
uspto-grants-1988_04
특허 번호
US04739095

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