[H-].[Na+].[CH3:3][O:4][C:5]1[C:11]2[S:12][CH:13]=[CH:14][C:10]=2[C:9](=O)[C:8]2[CH:16]=[CH:17][CH:18]=[CH:19][C:7]=2[CH:6]=1.O.Cl.[CH2:22]([O:24][C:25](=[O:27])[CH3:26])[CH3:23]>CS(C)=O.CN(C)C=O>[CH2:22]([O:24][C:25](=[O:27])[CH:26]=[C:9]1[C:10]2[CH:14]=[CH:13][S:12][C:11]=2[C:5]([O:4][CH3:3])=[CH:6][C:7]2[CH:19]=[CH:18][CH:17]=[CH:16][C:8]1=2)[CH3:23]21.6 g pre-dried NaH are suspended in 0.9 l dimethylsulfoxide and 200 g ethoxycarbonylmethylen-diethylphosphonate [(C2H5O)2POCH2COOC2H5 ] are added drop-wise over ca. 1 hour, the temperature being maintained at ca. 25°-30° C. by light cooling. The obtained mixture is then stirred for 30 minutes at room temperature and 121 g 10-methoxy-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-one dissolved with warming in 0.9 l dimethylformamide are then added in a single portion. The obtained reaction mixture is stirred for ca. 17 hours at ca. 95° C. under argon, and then stirred into a mixture of 7 l H2O/3 kg ice and 50 ml conc. HCl covered with a layer of 2 l ethylacetate. The organic phase is separated off and the aqueous phase extracted 3× with 2 l and 3× with 1 l ethyl acetate. The combined organic phases are washed 3× with 2 l H2O and 3× with 2 l saline, dried with MgSO4, filtered under suction and concentrated on a rotary evaporator to yield the title compound as a (Z,E)-isomer mixture: m.p.=91°-93° C.
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