Diethylene Glycol → 2-(2-((Tert-butyldimethylsilyl)oxy)ethoxy)ethanol

HRID 651504

반응식

HRID 651504 반응식
[CH2:1]([OH:7])[CH2:2][O:3][CH2:4][CH2:5][OH:6].[H-].[Na+].[Cl-].[CH3:11][SiH:12]([CH3:17])[C:13]([CH3:16])([CH3:15])[CH3:14]>O1CCCC1>[CH3:14][C:13]([Si:12]([CH3:17])([CH3:11])[O:7][CH2:1][CH2:2][O:3][CH2:4][CH2:5][OH:6])([CH3:16])[CH3:15]

참가 물질

5

반응물 3

HCID 8117Diethylene GlycolHCID 24758Sodium hydrideHCID 131722836Tert-butyldimethylsilane chloride

생성물 1

HCID 111175822-(2-((Tert-butyldimethylsilyl)oxy)ethoxy)ethanol수율 97.9%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

20 g of diethyleneglycol is added to 9.05 g of sodium hydride in 320 cm3 of tetrahydrofuran, the reaction medium is agitated for 45 minutes, 28.3 g of dimethylterbutylsilane chloride is added, agitation is carried out for 3 hours while leaving the temperature to return to ambient. Extraction is carried out with ether, followed by washing with an aqueous solution of sodium bicarbonate, with salt water, drying and evaporating the solvent. 40.25 g of expected product is obtained.

후처리

  1. waitagitation is carried out for 3 hours
  2. customwhile leaving the temperature
  3. extractionExtraction
  4. washby washing with an aqueous solution of sodium bicarbonate, with salt water
  5. customdrying
  6. customevaporating the solvent

출처 및 근거

ORD 기록
ord-ea06e4a76b824325b25c383d0b6d803b
출처 데이터셋
uspto-grants-2001_08
특허 번호
US06281204B1

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