Hydrochloric Acid → HCID 14456701, 화합물

HRID 654251노트

반응식

HRID 654251 반응식
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH:11](Br)[C:12]([OH:14])=O)=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[NH2:16][C:17](N)=[S:18].Cl.S1(CCCC1)(=O)=[O:22]>O>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH:11]2[S:18][C:17](=[O:22])[NH:16][C:12]2=[O:14])=[CH:8][CH:9]=1)(=[O:3])[CH3:2]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 31347SulfolaneHCID 2652713-(4-Acetylphenyl)-2-bromopropanoic acidHCID 2723790Thiourea

생성물 1

HCID 14456701HCID 14456701, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 3-(4-acetylphenyl)-2-bromopropanoic acid (87 g, 0.32 mol, prepared according to Cleland, Org. Synth. vol. 51, p. 1, 1971), and thiourea (48.7 g, 0.64 mol) in sulfolane (100 mL) was heated to 105°-110° C. for 5 hours. To this mixture was added a 2N HCl solution (162 mL) and the resulting solution was heated to 105°-110° C. overnight. After cooling and diluting with water, present title product was collected, washed with water and dried (75 g, 94%); mp 171°-172° C.

후처리

  1. temperaturethe resulting solution was heated to 105°-110° C. overnight
  2. temperatureAfter cooling

출처 및 근거

ORD 기록
ord-2b51b59555d54f58aa65fcab5fe7893a
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05130379

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