Hydrochloric Acid → HCID 85526988, 화합물

HRID 65488노트

반응식

HRID 65488 반응식
[C:1]1([CH2:7][CH:8]=[N:9][OH:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.ClCl.ClC1(CC=NO)C=CC=CC1.[CH3:24][C:25]([CH3:28])([O-:27])[CH3:26].[K+].Cl>C(Cl)(Cl)Cl.C(O)(C)(C)C>[C:25]([O:27][C:8](=[N:9][OH:10])[CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)([CH3:28])([CH3:26])[CH3:24]

참가 물질

8

반응물 5

HCID 313Hydrochloric AcidHCID 24526ChlorineHCID 99748PhenylacetaldoximeHCID 23665647Potassium tert-butoxide2회HCID 867410451-Chlorophenyl acetaldehyde oxime

생성물 1

HCID 85526988HCID 85526988, 화합물

시약·촉매·용매 2

HCID 6212Chloroform용매HCID 6386tert-Butanol용매

실험 절차

Using the procedure of Example I, phenyl acetaldehyde oxime in chloroform is reacted with chlorine gas introduced at -5° to 0° C. To the resulting solution of 1-chlorophenyl acetaldehyde oxime is added dropwise with stirring a solution of potassium t-butoxide in t-butanol. The reaction is allowed to go to completion and any residual potassium t-butoxide is neutralized with hydrogen chloride gas. The precipitated potassium chloride is removed by filtration, and the filtrate concentrated under reduced pressure to provide the desired 1-(t-butoxy)-2-phenyl acetaldehyde oxime.

후처리

  1. additionintroduced at -5° to 0° C
  2. customThe precipitated potassium chloride is removed by filtration
  3. concentrationthe filtrate concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-4877adffe60f4315972688612a661cb9
출처 데이터셋
uspto-grants-1986_09
특허 번호
US04614813

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