Azobisisobutyronitrile → Bromo-(2-iodophenyl)-acetic Acid Methyl Ester

HRID 660568

반응식

HRID 660568 반응식
[CH3:1][O:2][C:3](=[O:12])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[I:11].C1C(=O)N([Br:20])C(=O)C1.CC(N=NC(C#N)(C)C)(C#N)C>C(Cl)(Cl)(Cl)Cl>[CH3:1][O:2][C:3](=[O:12])[CH:4]([Br:20])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[I:11]

참가 물질

5

반응물 3

HCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 640185Methyl 2-(2-iodophenyl)acetate

생성물 1

HCID 86632576Bromo-(2-iodophenyl)-acetic Acid Methyl Ester

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

A mixture of (2-iodophenyl)-acetic acid methyl ester (14.5 g, 52.5 mmol), NBS (18.7 g, 105 mmol) and AIBN (1.72 g, 10.5 mmol) in CCl4 (300 mL) is refluxed for 10 h. The mixture is cooled to RT and the precipitate filtered. The filtrate is evaporated to give the title compound.

후처리

  1. temperatureis refluxed for 10 h
  2. filtrationthe precipitate filtered
  3. customThe filtrate is evaporated

출처 및 근거

ORD 기록
ord-db93df6fcc214a318294e7c39ea96e68
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084448B2

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