Hydrochloric Acid → 2-(Benzyloxy)-4-chlorobenzoic acid

HRID 660821

반응식

HRID 660821 반응식
C([O:8][C:9](=[O:25])[C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][C:11]=1[O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)C1C=CC=CC=1.[OH-].[Na+].Cl>CCO>[CH2:18]([O:17][C:11]1[CH:12]=[C:13]([Cl:16])[CH:14]=[CH:15][C:10]=1[C:9]([OH:25])=[O:8])[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66989997Benzyl 2-(benzyloxy)-4-chlorobenzoate

생성물 1

HCID 224521542-(Benzyloxy)-4-chlorobenzoic acid

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
60 °C

실험 절차

To a solution of 2-benzyloxy-4-chlorobenzoic acid benzyl ester in EtOH (500 mL) is added 1N NaOH (100 mL) and the mixture is stirred at 60° C. for 24 h. The mixture is allowed to cool to RT and is acidified with 1N HCl. The volume of the solution is reduced to 250 mL and the resulting precipitate is filtered, washed with water and dried to give the title compound as an off-white solid.

후처리

  1. temperatureto cool to RT
  2. filtrationthe resulting precipitate is filtered
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-838b99b9482146618fe143d268dbdd53
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084448B2

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