Hydrochloric Acid → 2-Chlorobenzo[d]thiazol-6-ol
반응식
[Cl-].[Al+3].[Cl-].[Cl-].C[O:6][C:7]1[CH:16]=[CH:15][C:10]2[N:11]=[C:12]([Cl:14])[S:13][C:9]=2[CH:8]=1.Cl>C1(C)C=CC=CC=1>[Cl:14][C:12]1[S:13][C:9]2[CH:8]=[C:7]([OH:6])[CH:16]=[CH:15][C:10]=2[N:11]=1참가 물질
5
반응 조건
- 온도
- 110 °C
실험 절차
Aluminum chloride (1.98 g, 14.9 mmol) was added to a solution of 6-methoxy-2-chlorobenzothiazole (1.06 g, 5.31 mmol) in toluene (40 mL), and the reaction mixture was heated to 110° C. After 1 h, the reaction mixture was allowed to cool to rt and 1 M aqueous HCl (40 mL) was added. The resulting precipitate was collected by filtration and washed with water (2×), saturated aqueous NaHCO3 (2×) and water (2×). The solid was air-dried, yielding 0.800 g (81%) of the title compound as a brown solid. LC-MS: RT=7.18 min., [M+H]+=185.9.
후처리
- temperatureto cool to rt
- filtrationThe resulting precipitate was collected by filtration
- washwashed with water (2×), saturated aqueous NaHCO3 (2×) and water (2×)
- customThe solid was air-dried
출처 및 근거
- ORD 기록
- ord-0734884e56114ec8b0502d47934f5e90
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08822472B2
반응 노트
불러오는 중…