Triphenylphosphine → 2-((2-(1H-pyrazol-4-yl)ethyl)thio)-5-chloroaniline

HRID 70370

반응식

HRID 70370 반응식
[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7]O)[CH:3]=[N:2]1.[NH2:9][C:10]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:11]=1[SH:17].C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.CC(OC(/N=N/C(OC(C)(C)C)=O)=O)(C)C>C(Cl)Cl>[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][S:17][C:11]2[CH:12]=[CH:13][C:14]([Cl:16])=[CH:15][C:10]=2[NH2:9])[CH:3]=[N:2]1

참가 물질

6

반응물 4

HCID 11776TriphenylphosphineHCID 120002-Amino-4-chlorobenzenethiolHCID 42936042-(1H-Pyrazol-4-yl)ethanolHCID 6034084Di-tert-butyl diazene-1,2-dicarboxylate

생성물 1

HCID 679728772-((2-(1H-pyrazol-4-yl)ethyl)thio)-5-chloroaniline

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Following the General Procedure J, the title intermediate was prepared from 2-(1H-pyrazol-4-yl) ethanol (472 mg, 4.218 mmol), 2-amino-4-chlorobenzenethiol (1.01 g, 6.327 mmol), PPh3 (2.21 g, 8.436 mmol) and di-tert-butylazodicarboxylate (1.9 g, 8.436 mmol) in CH2Cl2 (20 ml).

출처 및 근거

ORD 기록
ord-c8886a7c84de41818cd19b52db18dc58
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08822530B2

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