4-Hydroxybenzaldehyde → 4-Ethoxy-3-methoxybenzaldehyde

HRID 710432

반응식

[CH2:1](I)[CH3:2].[CH3:4][O:5][C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=1[OH:14])[CH:9]=[O:10].BrCCC.OC1C=CC(C=O)=CC=1>>[CH2:1]([O:14][C:13]1[CH:12]=[CH:11][C:8]([CH:9]=[O:10])=[CH:7][C:6]=1[O:5][CH3:4])[CH3:2]

참가 물질

반응물 4

HCID 1264-Hydroxybenzaldehyde

HCID 1183Vanillin

HCID 6340Iodoethane

HCID 78401-Bromopropane

생성물 1

HCID 671164-Ethoxy-3-methoxybenzaldehyde수율 90%

실험 절차

When the EtI and 3-methoxy-4-hydroxybenzaldehyde was substituted for 1-bromopropane and 4-hydroxybenzaldehyde respectively in Example 49, Step A, the identical process afforded the title compound in 90% yield, as light yellow oil. 1H-NMR (CDCl3) 1.49 (tr, 3H, J=6.98 Hz); 3.91 (s, 3H); 4.17 (q, 2H, J=14, 7 Hz); 6.94 (d, 1H, J=8.09 Hz); 7.38-7.43 (m, 2H); 9.02 (s, 1H).

출처 및 근거

ORD 기록: ord-063ab45ee3944c1fa1e1ad0a6ba6e8ab
출처 데이터셋: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09181182B2

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