Acetic Acid → 2-(Methylthio)-1H-pyrimidin-4-one

HRID 714773

반응식

HRID 714773 반응식
[S:1]=[C:2]1[NH:7][C:6](=[O:8])[CH:5]=[CH:4][NH:3]1.[OH-].[Na+].[C:11](O)(=O)C>O.IC>[CH3:11][S:1][C:2]1[NH:7][C:6](=[O:8])[CH:5]=[CH:4][N:3]=1

참가 물질

6

반응물 3

HCID 176Acetic AcidHCID 14798Sodium HydroxideHCID 1269845Thiouracil

생성물 1

HCID 798232-(Methylthio)-1H-pyrimidin-4-one

시약·촉매·용매 2

HCID 962Water용매HCID 6328Methyl iodide용매

실험 절차

To 2-thioxo-2,3-dihydropyrimidin-4(1H)-one (21 g) was added dropwise a solution of sodium hydroxide (13 g) in water (120 mL), iodomethane (11.5 mL) was added thereto, and the mixture was stirred overnight at room temperature. To the reaction mixture was added acetic acid (9.5 mL), and the resulting solid was collected by filtration. The obtained solid was washed with cold water to give the title compound (24 g).

후처리

  1. additionwas added
  2. filtrationthe resulting solid was collected by filtration
  3. washThe obtained solid was washed with cold water

출처 및 근거

ORD 기록
ord-34b66474704041fea99a3a36c45d8f29
출처 데이터셋
uspto-grants-2015_11
특허 번호
US09187453B2

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