Iodoethane → 5-Ethoxy-1-tetralone

HRID 719173노트

반응식

HRID 719173 반응식
[OH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH2:6][C:7]2=[O:12].[OH-].[Na+].[CH2:15](I)[CH3:16]>C(O)C.Cl>[CH2:15]([O:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH2:6][C:7]2=[O:12])[CH3:16]

참가 물질

6

반응물 3

HCID 6340IodoethaneHCID 14798Sodium HydroxideHCID 1199215-Hydroxy-1-tetralone

생성물 1

HCID 218967975-Ethoxy-1-tetralone

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 702Ethanol용매

실험 절차

A mixture of 5-hydroxy-1-tetralone (2.00 g) and sodium hydroxide (493 mg) was warmed in ethanol (40 mL) to 50° C. Ethyl iodide (3.94 mL) was then added and the reaction mixture was heated at reflux for 16 hours. The reaction mixture was diluted with 2N hydrochloric acid, extracted into ethyl acetate, dried and the solvent removed in vacuo to yield 5-ethoxy-1-tetralone as a white solid (2.06 g)

후처리

  1. temperaturethe reaction mixture was heated
  2. temperatureat reflux for 16 hours
  3. extractionextracted into ethyl acetate
  4. customdried
  5. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-b0e0134a1c8b4877b7660496db6f4dc1
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07132419B2

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