Hydrochloric Acid → (3,5-Dibromophenyl)methanol
반응식
[BH4-].[Na+].[Br:3][C:4]1[CH:5]=[C:6]([CH:9]=[C:10]([Br:12])[CH:11]=1)[CH:7]=[O:8].Cl>CO>[Br:3][C:4]1[CH:5]=[C:6]([CH:9]=[C:10]([Br:12])[CH:11]=1)[CH2:7][OH:8]참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
Sodium borohydride (0.75 g) was added portionwise to a stirred suspension of 3,5-dibromobenzaldehyde (10.46 g) in methanol (50 ml) at 0° C. The mixture was stirred at 0° C. for 30 minutes, allowed to warm to room temperature and then its pH was adjusted to 2 using concentrated hydrochloric acid. Evaporation under vacuum provided a residue which was partitioned between ethyl acetate and water. The organic phase was washed with water, dried(MgSO4), then evaporated under vacuum to furnish the title compound as a solid (10.0 g), m.p. 103°-104° C. Found: C, 31.98; H, 2.23. C7H6Br2O requires C, 31.61; H, 2.77%.
후처리
- temperatureto warm to room temperature
- customEvaporation under vacuum
- customprovided a residue which
- customwas partitioned between ethyl acetate and water
- washThe organic phase was washed with water, dried(MgSO4)
- customevaporated under vacuum
출처 및 근거
- ORD 기록
- ord-6a31763ce7e5436b85040d5a4941718f
- 출처 데이터셋
- uspto-grants-1998_01
- 특허 번호
- US05705523
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