반응식
[CH2:1](Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:9]([OH:12])[C:10]#[CH:11].[OH-].[Na+]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C1(C)C=CC=CC=1.O>[CH2:9]([O:12][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C:10]#[CH:11]참가 물질
7
반응 조건
- 온도
- 50 °C
실험 절차
Tetrabutylammonium bromide (19.34 g, 600 mmol) was added to a solution of benzylbromide (71.3 ml, 600 mmol) and propargyl alcohol (35.5 ml, 600 mmol) in 270 ml of toluene and the mixture was heated to 50° C. A solution of sodium hydroxide (24 g, 600 mmol) in 55 ml of water was then added dropwise over a period of 1 hour and stirring was continued for another 3 hours. The reaction mixture was then cooled to 25° C. and transferred into a separatory funnel. The aqueous layer was removed and the organic layer was washed three times with 150 ml of brine. Residual water was removed by repeated azeotropic distillation using toluene. A pale yellow liquid was obtained. Yield: 81.9 g (93.4 %).
후처리
- temperatureThe reaction mixture was then cooled to 25° C.
- customtransferred into a separatory funnel
- customThe aqueous layer was removed
- washthe organic layer was washed three times with 150 ml of brine
- customResidual water was removed
- distillationdistillation
- customA pale yellow liquid was obtained
출처 및 근거
- ORD 기록
- ord-4bd27bcd43134be8bb64bdb2444da58d
- 출처 데이터셋
- uspto-grants-2009_09
- 특허 번호
- US07589091B2
연결된 노트
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