2-Tert-Butylphenol → 4-Bromo-2-tert-butylphenol

HRID 73996

반응식

HRID 73996 반응식
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[OH:11])([CH3:4])([CH3:3])[CH3:2].C1C(=O)N([Br:19])C(=O)C1>CC#N>[C:1]([C:5]1[CH:10]=[C:9]([Br:19])[CH:8]=[CH:7][C:6]=1[OH:11])([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 2

HCID 69232-Tert-ButylphenolHCID 67184N-bromobutanimide

생성물 1

HCID 970684-Bromo-2-tert-butylphenol수율 99.3%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a solution of 2-tert-butylphenol (250 g, 1.67 mol) in CH3CN (1500 mL) was added NBS (300 g, 1.67 mol) at room temperature. After addition, the mixture was stirred at room temperature overnight and then the solvent was removed. Petroleum ether (1000 mL) was added, and the resulting white precipitate was filtered off. The filtrate was concentrated under reduced pressure to give the crude 2-tert-butyl-4-bromophenol (380 g), which was used without further purification.

후처리

  1. additionAfter addition
  2. customthe solvent was removed
  3. additionPetroleum ether (1000 mL) was added
  4. filtrationthe resulting white precipitate was filtered off
  5. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-97ca45fe2d5043acb3e89dba7009a4e9
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829204B2

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