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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Pamidronic Acid → Alendronic Acid

HRID 74141
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HRID 74141 반응식
[CH2:1]([C:4]([P:10]([OH:13])([OH:12])=[O:11])([P:6]([OH:9])([OH:8])=[O:7])[OH:5])[CH2:2]N.C[CH2:15][N:16](CC)CC>O>[CH2:2]([CH2:15][NH2:16])[CH2:1][C:4]([P:10]([OH:13])([OH:12])=[O:11])([P:6]([OH:9])([OH:8])=[O:7])[OH:5]
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참가 물질

4

반응물 2

HCID 4674Pamidronic AcidHCID 8471Triethylamine

생성물 1

HCID 2088Alendronic Acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The NHS ester (0.35 g, 0.62 mmol) was dissolved in H2O (30 mL), and pamidronate (0.52 g, 2.23 mmol) and Et3N (1.7 mL, 12.4 mmol) were added. The reaction solution was stirred for 24 h at room temperature. Subsequently, the H2O was removed in the vacuum. The product obtained was purified by means of HPLC.

후처리

  1. customSubsequently, the H2O was removed in the vacuum
  2. customThe product obtained
  3. customwas purified by means of HPLC

출처 및 근거

ORD 기록
ord-63709912d71b4b3b8f382421cafd90e3
출처 데이터셋
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08829233B2

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