Sodium Hydroxide → 1-[3-(4-tert-Butylphenyl)-2-methylpropyl]-4-methylpiperazine

HRID 745485

반응식

HRID 745485 반응식
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([CH3:15])[CH2:13]Cl)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:16][N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1.[OH-].[Na+]>CCOCC>[CH3:16][N:17]1[CH2:22][CH2:21][N:20]([CH2:13][CH:12]([CH3:15])[CH2:11][C:8]2[CH:9]=[CH:10][C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:6][CH:7]=2)[CH2:19][CH2:18]1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 531671-MethylpiperazineHCID 132518171-tert-Butyl-4-(3-chloro-2-methylpropyl)benzene

생성물 1

HCID 132519811-[3-(4-tert-Butylphenyl)-2-methylpropyl]-4-methylpiperazine수율 93.6%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

533 g of 3-(4-tert.butylphenyl)-2-methylpropyl chloride and 714 g of 4-methylpiperazine were stirred for 7 hours at 140° C. and then cooled to +10° C. in an ice bath, and 400 ml of 50% strength sodium hyroxide solution were added slowly, followed by the addition of 500 ml of ether. The organic phase was separated off, dried over sodium hydroxide and distilled to give 640 g of 1-methyl-4-[3-(4-tert.-butylphenyl)-2-methylpropyl]-piperazine of boiling point 135°-140° C./0.3 mbar.

후처리

  1. temperaturecooled to +10° C. in an ice bath
  2. customThe organic phase was separated off
  3. dry with materialdried over sodium hydroxide
  4. distillationdistilled

출처 및 근거

ORD 기록
ord-8bdee9547f6c4f59aa42d2195697c970
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04599335

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