Tricyclohexylphosphine → 3-(2-(2-(cyclopropylamino)pyrimidin-5-yl)ethynyl)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide

반응식

[C:1]([C:3]1[CH:4]=[C:5]([CH:25]=[CH:26][C:27]=1[CH3:28])[C:6]([NH:8][C:9]1[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:12]=[C:11]([N:19]2[CH:23]=[C:22]([CH3:24])[N:21]=[CH:20]2)[CH:10]=1)=[O:7])#[CH:2].Br[C:30]1[CH:31]=[N:32][C:33]([NH:36][CH:37]2[CH2:39][CH2:38]2)=[N:34][CH:35]=1.C1(P(C2CCCCC2)C2CCCCC2)CCCCC1.CCN(C(C)C)C(C)C>[Cu]I.CC([O-])=O.CC([O-])=O.[Pd+2]>[CH:37]1([NH:36][C:33]2[N:34]=[CH:35][C:30]([C:2]#[C:1][C:3]3[CH:4]=[C:5]([CH:25]=[CH:26][C:27]=3[CH3:28])[C:6]([NH:8][C:9]3[CH:14]=[C:13]([C:15]([F:16])([F:17])[F:18])[CH:12]=[C:11]([N:19]4[CH:23]=[C:22]([CH3:24])[N:21]=[CH:20]4)[CH:10]=3)=[O:7])=[CH:31][N:32]=2)[CH2:39][CH2:38]1