Nicotinic Acid → 2-Benzoyl amino-pentane dioic acid dimethyl ester
반응식
[CH:1]1[CH:6]=N[CH:4]=[C:3]([C:7]([OH:9])=O)[CH:2]=1.[CH3:10]N1CCOCC1.CCN=C=NCCCN(C)C.Cl.[CH3:29][O:30][C:31](=[O:40])[C@H:32]([CH2:34][CH2:35][C:36]([O:38][CH3:39])=[O:37])[NH2:33]>C(Cl)Cl>[CH3:29][O:30][C:31](=[O:40])[C:32]([NH2:33])([C:7](=[O:9])[C:3]1[CH:2]=[CH:1][CH:6]=[CH:10][CH:4]=1)[CH2:34][CH2:35][C:36]([O:38][CH3:39])=[O:37]참가 물질
6
반응 조건
- 온도
- 25 °C
실험 절차
To a solution of niacin (1.4 g, 11.42 mmol) in DCM (20 mL) were added N-methyl morpholine (3.76 mL, 34.2 mmol), EDCI.HCl (4.36 g, 34.2 mmol) and L-glutamic acid dimethyl ester (2.0 g, 11.42 mmol). The mixture was allowed to stir at room temperature (25° C.) over 3 h under nitrogen atmosphere. The resulting mixture was diluted with DCM (100 mL), washed with water (3×50 mL) and dried over sodium sulphate. The crude product obtained upon evaporation of the solvent was further purified by silica gel column chromatography to obtain required product as pale yellow oil (3.1 g, 73%).
후처리
- washwashed with water (3×50 mL)
- dry with materialdried over sodium sulphate
- customThe crude product obtained upon evaporation of the solvent
- customwas further purified by silica gel column chromatography
출처 및 근거
- ORD 기록
- ord-466ad572ab5643d8b303080aa2f9a680
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08846721B2
반응 노트
불러오는 중…