홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Sodium hydride → HCID 58577627, 화합물

HRID 82522
노트
인쇄 미리보기

반응식

HRID 82522 반응식
Cl[CH2:2][O:3][CH2:4][CH2:5][Si:6]([CH3:9])([CH3:8])[CH3:7].[CH2:10]([O:17][C:18]1[CH:23]=[CH:22][C:21]([N:24]2[C:28]3=[N:29][CH:30]=[CH:31][CH:32]=[C:27]3[NH:26][C:25]2=[O:33])=[CH:20][CH:19]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[H-].[Na+].[Cl-].[Cl-].[Ca+2]>CN(C=O)C.CO>[CH2:10]([O:17][C:18]1[CH:19]=[CH:20][C:21]([N:24]2[C:28]3=[N:29][CH:30]=[CH:31][CH:32]=[C:27]3[N:26]([CH2:2][O:3][CH2:4][CH2:5][Si:6]([CH3:9])([CH3:8])[CH3:7])[C:25]2=[O:33])=[CH:22][CH:23]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 24758Sodium hydrideHCID 27242712-Chloromethyl 2-(trimethylsilyl)ethyl etherHCID 5284359Calcium ChlorideHCID 585776613-[4-(benzyloxy)phenyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one

생성물 1

HCID 58577627HCID 58577627, 화합물

시약·촉매·용매 2

HCID 887
Methanol
용매
HCID 6228Dimethylformamide용매

실험 절차

[2-(Chloromethoxy)ethyl](trimethyl)silane (1.673 mL) was added to a solution of 3-[4-(benzyloxy)phenyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one (2.0 g) and sodium hydride (0.504 g) (60% in mineral oil) in DMF (5.0 mL) at 0° C. The mixture was stirred at room temperature under a dry atmosphere (CaCl2 tube) for 1 h. After the reaction, the reaction mixture was diluted with MeOH and concentrated in vacuo. The residue was purified by column chromatography (silica gel, eluted with 0%-100% EtOAc in hexane) to give 3-[4-(benzyloxy)phenyl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one (2.75 g) as a white solid.

후처리

  1. customAfter the reaction
  2. concentrationconcentrated in vacuo
  3. customThe residue was purified by column chromatography (silica gel, eluted with 0%-100% EtOAc in hexane)

출처 및 근거

ORD 기록
ord-70aea1be78a248d5a5f9b5586710833a
출처 데이터셋
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08846713B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트