Sodium Hydroxide → HCID 20324959, 화합물
반응식
[CH2:1]([C:5]1[N:10]2[N:11]=[CH:12][CH:13]=[C:9]2[N:8]=[C:7]([CH3:14])[CH:6]=1)[CH:2]([CH3:4])[CH3:3].[Br:15]N1C(=O)CCC1=O.[OH-].[Na+]>C(Cl)(Cl)Cl>[Br:15][C:13]1[CH:12]=[N:11][N:10]2[C:5]([CH2:1][CH:2]([CH3:4])[CH3:3])=[CH:6][C:7]([CH3:14])=[N:8][C:9]=12참가 물질
5
실험 절차
A solution of 7.5 g (0.026 mol) of 7-isobutyl-5-methylpyrazolo-[1,5-a]pyrimidine in 60 ml chloroform was treated with 4.6 gm (0.026 mol) of N-bromosuccinimide. The mixture was stirred at ambient temperature and then allowed to cool overnight in the refrigerator. The mixture was then poured over ice (100 gm), rendered alkaline with 6N NaOH, and extracted with chloroform. The chloroform solution was separated, dried (Na2SO4), and distilled to yield 5.5 gm, (47%) of a light yellow, viscous oil, b.p. 127°-129° /1.5 mm.
후처리
- temperatureto cool overnight in the refrigerator
- extractionextracted with chloroform
- customThe chloroform solution was separated
- dry with materialdried (Na2SO4)
- distillationdistilled
- customto yield 5.5 gm, (47%) of a light yellow, viscous oil, b.p. 127°-129° /1.5 mm
출처 및 근거
- ORD 기록
- ord-13be8c0a0b804772ab19f03deb2a628c
- 출처 데이터셋
- uspto-grants-1978_06
- 특허 번호
- US04093617
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