Methyl iodide → Tert-butyl tert-butyl(2-((2-chlorophenyl)(methyl)carbamoyl)-4,5-dihydropyrido[4,3-b]thieno[2,3-d]oxepin-8-yl)carbamate

HRID 84600

반응식

[C:1]([N:5]([C:13]1[N:23]=[CH:22][C:21]2[C:20]3[S:24][C:25]([C:27](=[O:36])[NH:28][C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=4[Cl:35])=[CH:26][C:19]=3[CH2:18][CH2:17][O:16][C:15]=2[CH:14]=1)[C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9])([CH3:4])([CH3:3])[CH3:2].[CH3:37]I.[H-].[Na+]>>[C:1]([N:5]([C:13]1[N:23]=[CH:22][C:21]2[C:20]3[S:24][C:25]([C:27](=[O:36])[N:28]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=4[Cl:35])[CH3:37])=[CH:26][C:19]=3[CH2:18][CH2:17][O:16][C:15]=2[CH:14]=1)[C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9])([CH3:2])([CH3:3])[CH3:4]

참가 물질

반응물 3

HCID 6328Methyl iodide

HCID 24758Sodium hydride

HCID 57900446tert-Butyl tert-butyl(2-(2-chlorophenylcarbamoyl)-4,5-dihydropyrido[4,3-b]thieno[2,3-d]oxepin-8-yl)carbamate

생성물 1

HCID 57900249Tert-butyl tert-butyl(2-((2-chlorophenyl)(methyl)carbamoyl)-4,5-dihydropyrido[4,3-b]thieno[2,3-d]oxepin-8-yl)carbamate수율 78%

실험 절차

Following Scheme 4, tert-butyl tert-butyl(2-(2-chlorophenylcarbamoyl)-4,5-dihydropyrido[4,3-b]thieno[2,3-d]oxepin-8-yl)carbamate, methyl iodide and sodium hydride were reacted to give tert-butyl tert-butyl(2-((2-chlorophenyl)(methyl)carbamoyl)-4,5-dihydropyrido[4,3-b]thieno[2,3-d]oxepin-8-yl)carbamate (78%). MS: (ESI+) 542.3

후처리

customwere reacted

출처 및 근거

ORD 기록: ord-ff37a9b2120f4d91b597578651acbfb1
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08846762B2

연결된 노트

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