Hydrochloric Acid → 1-[4-(Methylthio)phenyl]-1-propanone

HRID 846234노트

반응식

HRID 846234 반응식
[C:1]1([S:7][CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:9](Cl)(=[O:12])[CH2:10][CH3:11].[Al+3].[Cl-].[Cl-].[Cl-].Cl>ClC(Cl)C.O>[CH3:8][S:7][C:1]1[CH:6]=[CH:5][C:4]([C:9](=[O:12])[CH2:10][CH3:11])=[CH:3][CH:2]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 7520ThioanisoleHCID 62324Propionyl chlorideHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 8211711-[4-(Methylthio)phenyl]-1-propanone

시약·촉매·용매 2

HCID 962Water용매HCID 63651,1-Dichloroethane용매

실험 절차

To a mixture of thioanisole (5.0 g) and propionyl chloride (3.9 ml) at 0° C. in dichloroethane (80 ml) was added AlCl3 (6.4 g) in portions. The mixture was stirred 12 hours at ambient temperature, poured into water (200 ml) and conc. HCl (2 ml), then extracted with CH2Cl2. The extract was reduced to dryness to provide the title compound mp 60°-61° C. after purification by chromatography on silica gel.

후처리

  1. extractionextracted with CH2Cl2

출처 및 근거

ORD 기록
ord-78d5b8b098dc4f279cc9c0013bc77c03
출처 데이터셋
uspto-grants-1992_08
특허 번호
US05135940

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