Acetonitrile → Triphenylphosphine

HRID 846246

반응식

HRID 846246 반응식
O[NH-].[O:3]1[CH2:7][CH2:6]C[CH2:4]1.C(#[N:10])C.[C:11]1([P:17]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(Cl)(Cl)(Cl)Cl.C(Cl)(Cl)Cl>[C:24]1([P:17]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1.[O:3]1[CH2:7][CH2:6][N:10]=[CH:4]1

참가 물질

8

반응물 4

HCID 6342AcetonitrileHCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 178514248HCID 178514248, 화합물

생성물 2

HCID 11776TriphenylphosphineHCID 68157Oxazoline

시약·촉매·용매 2

HCID 5943Carbon Tetrachloride용매HCID 6212Chloroform용매

실험 절차

Hydroxyamide IX is then subjected to cyclodehydration in an inert organic solvent (e.g., tetrahydrofuran, acetonitrile or chloroform) under an inert atmosphere (e.g., argon) with triphenylphosphine (employing a molar ratio of V:triphenylphosphine of from about 0.8:1 to about 1:1) and carbon tetrachloride in the presence of an amine base (e.g., triethylamine or diisopropylethylamine) to form oxazoline ##STR23##

출처 및 근거

ORD 기록
ord-9faeadff4ef440cda5bbff849c7c2f54
출처 데이터셋
uspto-grants-1992_08
특허 번호
US05135939

연결된 노트

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