Baclofen → 4-(4-Chlorophenyl)-2-pyrrolidinone

HRID 885413

반응식

HRID 885413 반응식
[CH:1]1[C:6]([CH:7]([CH2:12][NH2:13])[CH2:8][C:9](O)=[O:10])=[CH:5][CH:4]=[C:3]([Cl:14])[CH:2]=1.S(Cl)(Cl)=O.C(N(C(C)C)CC)(C)C>C(Cl)Cl>[Cl:14][C:3]1[CH:4]=[CH:5][C:6]([CH:7]2[CH2:12][NH:13][C:9](=[O:10])[CH2:8]2)=[CH:1][CH:2]=1

참가 물질

5

반응물 3

HCID 2284BaclofenHCID 24386Thionyl ChlorideHCID 81531Diisopropylethylamine

생성물 1

HCID 1854904-(4-Chlorophenyl)-2-pyrrolidinone

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To Baclofen (1.0 g, 4.7 mmol) in CH2Cl2 (20 mL) was added thionyl chloride (0.38 mL, 5.2 mmol), and the reaction was stirred for 10 minutes. Diisopropylethylamine (1.5 mL) was added, and the mixture was worked-up to give the title compound.

출처 및 근거

ORD 기록
ord-417fc5766c154604aeaddd8638a0c2ee
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08242145B2

연결된 노트

불러오는 중…