Triethylamine → 122570-36-9

HRID 903584

반응식

HRID 903584 반응식
Cl.[NH2:2][CH2:3][CH2:4][C:5]1[CH:12]=[CH:11][C:9]([OH:10])=[C:7]([OH:8])[CH:6]=1.[C:13]([NH:16][C@H:17]([C:22](O)=[O:23])[CH2:18][CH2:19][S:20][CH3:21])(=[O:15])[CH3:14].C(N(CC)CC)C>CN(C)C=O>[C:13]([NH:16][C@H:17]([C:22]([NH:2][CH2:3][CH2:4][C:5]1[CH:12]=[CH:11][C:9]([OH:10])=[C:7]([OH:8])[CH:6]=1)=[O:23])[CH2:18][CH2:19][S:20][CH3:21])(=[O:15])[CH3:14]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 65340Dopamine HydrochlorideHCID 448580N-acetyl-L-methionine

생성물 1

HCID 22812625122570-36-9

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2.85 g of dopamine hydrochloride, 4.32 g of N-hydroxysuccinimide ester of N-acetyl-L-methionine, 3.04 g of triethylamine and 15 ml of dimethylformamide are treated in the same manner as described in Example 5. After the reaction, the mixture is condensed under reduced pressure to remove solvent. The residue is dissolve in ethyl acetate, washed with water and dried. The solution is condensed to remove solvent. 3.1 g of N-(N-acetyl-L-methionyl)-dopamine are obtained as caramel.

후처리

  1. customAfter the reaction
  2. customcondensed under reduced pressure
  3. customto remove solvent
  4. dissolutionThe residue is dissolve in ethyl acetate
  5. washwashed with water
  6. customdried
  7. customcondensed
  8. customto remove solvent

출처 및 근거

ORD 기록
ord-6823c088a7c342818f6492ad5f3a1b94
출처 데이터셋
uspto-grants-1980_10
특허 번호
US04228183

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