Water → 4-Bromo-1-(bromomethyl)-2-chlorobenzene

HRID 906492

반응식

HRID 906492 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[CH:4][C:3]=1[CH3:9].C1C(=O)N([Br:17])C(=O)C1.CC(N=NC(C#N)(C)C)(C#N)C.O>C(Cl)(Cl)(Cl)Cl>[Br:8][C:6]1[CH:5]=[CH:4][C:3]([CH2:9][Br:17])=[C:2]([Cl:1])[CH:7]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 27355544-Bromo-2-chlorotoluene

생성물 1

HCID 219144864-Bromo-1-(bromomethyl)-2-chlorobenzene수율 55.3%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

5.0 g of 2-chloro-4-bromotoluene are dissolved in 120 ml of CCl4. 4.3 g of NBS and 1.6 g of AIBN are added. The mixture is heated at reflux for 15 hours, water is added, the two phases are separated and then extraction is carried out with CH2Cl2. Purification is carried out by chromatography on a silica column eluted with petroleum ether. 3.8 g of liquid are obtained.

후처리

  1. temperatureThe mixture is heated
  2. temperatureat reflux for 15 hours
  3. customthe two phases are separated
  4. extractionextraction
  5. customPurification
  6. washeluted with petroleum ether

출처 및 근거

ORD 기록
ord-1d17187996294ba3befa45d30c8cc81c
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08012991B2

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