2,6-Dimethylphenol → 2-Chloro-4-(2,6-dimethylphenoxy)pyridine

HRID 910992

반응식

HRID 910992 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[OH:9].[H-].[Na+].[Cl:12][C:13]1[CH:18]=[C:17]([N+]([O-])=O)[CH:16]=[CH:15][N:14]=1>>[Cl:12][C:13]1[CH:18]=[C:17]([O:9][C:3]2[C:4]([CH3:8])=[CH:5][CH:6]=[CH:7][C:2]=2[CH3:1])[CH:16]=[CH:15][N:14]=1

참가 물질

4

반응물 3

HCID 113352,6-DimethylphenolHCID 24758Sodium hydrideHCID 7351522-Chloro-4-nitropyridine

생성물 1

HCID 866347362-Chloro-4-(2,6-dimethylphenoxy)pyridine수율 96.3%

실험 절차

Using the method of Example 3, Step A, 2,6-dimethylphenol (0.771 g, 6.31 mmol), 60% sodium hydride in mineral oil (252 mg, 6.31 mmol), and 2-chloro-4-nitropyridine (1.00 g, 6.31 mmol) were reacted to provide 2-chloro-4-(2,6-dimethylphenoxy)pyridine (1.42 g, 96% yield) as a white solid. 1H NMR (CDCl3) δ 8.20 (d, 1H), 7.12 (s, 4H), 6.65-6.68 (m, 2H), 2.11 (s, 6H).

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-4063f08ca8f346c7ad8604fa9a1f063c
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022222B2

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