Hydrochloric Acid → HCID 57955517, 화합물
반응식
[Cl:1][C:2]1[N:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[C:9]([F:14])([F:13])[CH2:8][N:7]([CH:15]3[CH2:19][CH2:18][C@@H:17]([CH3:20])[CH2:16]3)[C:6]=2[N:21]=1.[H-].[Na+].[CH3:24]I.Cl>>[Cl:1][C:2]1[N:3]=[CH:4][C:5]2[N:11]([CH3:24])[C:10](=[O:12])[C:9]([F:14])([F:13])[CH2:8][N:7]([CH:15]3[CH2:19][CH2:18][C@@H:17]([CH3:20])[CH2:16]3)[C:6]=2[N:21]=1참가 물질
5
실험 절차
2-Chloro-7,7-difluoro-9-((3R)-3-methylcyclopentyl)-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one was methylated on 5-position using sodium hydride and methyl iodide. After 30 minutes the reaction was deemed complete by LCMS, poured into ice, the solution acidified with 1N HCl, the product filtered off as a tan solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.91-2.22 (m, 10H) 3.34 (s, 3H) 4.04-4.35 (m, 2H) 4.72-5.04 (m, 1H) 8.35 (s, 1H). m/z 331.2 (M+H)+.