Hydrochloric Acid → 4-([(6-Bromo-1,3-benzothiazol-2-yl)amino]carbonylamino)butanoic acid

HRID 9163

반응식

HRID 9163 반응식
[Br:1][C:2]1[CH:22]=[CH:21][C:5]2[N:6]=[C:7]([NH:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][C:16]([O:18]CC)=[O:17])=[O:11])[S:8][C:4]=2[CH:3]=1.[OH-].[Na+].Cl>C1COCC1.CCO>[Br:1][C:2]1[CH:22]=[CH:21][C:5]2[N:6]=[C:7]([NH:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[O:11])[S:8][C:4]=2[CH:3]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 21985597Ethyl 4-([(6-bromo-1,3-benzothiazol-2-yl)amino]carbonylamino)butanoate

생성물 1

HCID 219856244-([(6-Bromo-1,3-benzothiazol-2-yl)amino]carbonylamino)butanoic acid수율 15.4%

시약·촉매·용매 1

HCID 21873804Tetrahydrofuran ethanol용매

반응 조건

온도
20 °C

실험 절차

To a solution of ethyl 4-([(6-bromo-1,3-benzothiazol-2-yl)amino]carbonylamino)-butanoate (175 mg, 0.453 mmol) in THF/EtOH (1/1, 3 mL) was added 2 M NaOH (2.26 mL, 4.53 mmol). The reaction mixture was stirred at about 20° C. for about 3 hrs then 2 M HCl was added until pH<6 and a white precipitate was formed. The precipitate was filtered off and washed with H2O. 25 mg (15%) pure product was isolated.

후처리

  1. customa white precipitate was formed
  2. filtrationThe precipitate was filtered off
  3. washwashed with H2O

출처 및 근거

ORD 기록
ord-eeb2af849bb244f29f28bc6c0698016c
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091227B2

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