Hydrochloric Acid → N-nonanoyl tyramine

HRID 963536

반응식

HRID 963536 반응식
[C:1](Cl)(=[O:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[NH2:12][CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=1.C(N(CC)CC)C.Cl>O1CCCC1O>[C:1]([NH:12][CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=1)(=[O:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 5610TyramineHCID 8471TriethylamineHCID 69819Nonanoyl chloride

생성물 1

HCID 15343996N-nonanoyl tyramine

시약·촉매·용매 1

HCID 93002Tetrahydro-2-hydroxyfuran용매

실험 절차

N-nonanoyl tyramine was prepared by adding dropwise about 2.74 moles of nonanoyl chloride to a cooled solution comprising about 1.0 g tyramine and about 2.03 ml of triethylamine in 35 ml of tetrahydrofuranol (THF). The reaction mixture was stirred at room temperature for 48 hours. It was then poured into about 70 ml of 10% HCl solution and the mixture extracted with ethyl acetate (3×50 ml). The ethyl acetate layer was separated, dried (MgSO4) and concentrated under reduced pressure to give a crude N-nonanoyl tyramine product. The product was purified by chromatography on a silica gel column eluted with methylene chloride/ethyl acetate (30:1).

후처리

  1. customN-nonanoyl tyramine was prepared
  2. extractionthe mixture extracted with ethyl acetate (3×50 ml)
  3. customThe ethyl acetate layer was separated
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-1981fe78058e43c7bbe3adf5b6e10072
출처 데이터셋
uspto-grants-1998_06
특허 번호
US05763492

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