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Triethylamine → HCID 69411206, 화합물

HRID 970047
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HRID 970047 반응식
FC(F)(F)S(O[C:7]1[CH:8]=[CH:9][C:10]2[CH:16]=[CH:15][C:14]3[CH:17]=[CH:18][CH:19]=[CH:20][C:13]=3[C:12](=[O:21])[C:11]=2[CH:22]=1)(=O)=O.[Cl:25][C:26]1[CH:35]=[C:34]2[C:29]([CH:30]=[CH:31][C:32]([CH:36]=[CH2:37])=[N:33]2)=[CH:28][CH:27]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[Br-].[Li+].C(N(CC)CC)C>CN(C)C=O.C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[Cl:25][C:26]1[CH:35]=[C:34]2[C:29]([CH:30]=[CH:31][C:32](/[CH:36]=[CH:37]/[C:7]3[CH:8]=[CH:9][C:10]4[CH:16]=[CH:15][C:14]5[CH:17]=[CH:18][CH:19]=[CH:20][C:13]=5[C:12](=[O:21])[C:11]=4[CH:22]=3)=[N:33]2)=[CH:28][CH:27]=1
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참가 물질

8

반응물 5

HCID 8471TriethylamineHCID 11776TriphenylphosphineHCID 82050Lithium BromideHCID 107028207-Chloro-2-vinylquinolineHCID 59018481HCID 59018481, 화합물

생성물 1

HCID 69411206HCID 69411206, 화합물

시약·촉매·용매 2

HCID 167845
palladium(II) acetate
촉매
HCID 6228Dimethylformamide용매

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온도
120 °C

실험 절차

In 30 ml of N,N-dimethylformamide were dissolved 0.89 g (2.5 mmol) of 3-trifluoromethanesulfonyloxy-5H-dibenzo[a,d]cyclohepten-5-one and 0.48 g (2.5 mmol) of 7-chloro-2-vinyl quinoline, and then, 100 mg (0.5 mmol) of palladium acetate, 420 mg (1.6 mmol) of triphenylphosphine and 2.1 g (24 mmol) of lithium bromide were added to the mixture and the atmosphere thereof was made nitrogen. Then, 5.0 ml (36 mmol) of triethylamine was added to the mixture, and the resulting mixture was stirred under nitrogen atmosphere at 120° C. for 10 hours.

출처 및 근거

ORD 기록
ord-1fc1525cf00f43a8911c6210eed61521
출처 데이터셋
uspto-grants-2007_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07309718B2

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