p-Toluenesulfonic acid → 1-(2-Bromo-1,1-dimethoxyethyl)-2,4-dichlorobenzene

HRID 971643

반응식

HRID 971643 반응식
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:6]=1[Cl:12])=[O:4].[CH3:13][O:14]C(OC)OC.[CH3:20]C1C=CC(S(O)(=O)=O)=CC=1.[Cl-].[Cl-].[Ca+2].[OH-].[Na+]>O(CC)CC.CO>[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:6]=1[Cl:12])([O:14][CH3:13])[O:4][CH3:20]

참가 물질

8

반응물 5

HCID 6101p-Toluenesulfonic acidHCID 9005Trimethyl orthoformateHCID 14798Sodium HydroxideHCID 758282-Bromo-1-(2,4-dichlorophenyl)ethan-1-oneHCID 5284359Calcium Chloride

생성물 1

HCID 127058821-(2-Bromo-1,1-dimethoxyethyl)-2,4-dichlorobenzene수율 92%

시약·촉매·용매 2

HCID 887Methanol용매HCID 3283Diethyl Ether용매

실험 절차

A mixture of 13.5 parts of 2-bromo-1-(2,4-dichlorophenyl)ethanone, 5.5 parts of trimethoxymethane, 2 parts of 4-methylbenzenesulfonic acid and 80 parts of methanol is stirred and refluxed overnight (CaCl2 -tube). The reaction mixture is cooled and stirred for 30 minutes with 15 parts of a sodium hydroxide solution 50%. Then there are added 140 parts of 1,1'-oxybisethane and the mixture is washed with 300 parts of water. The organic phase is stirred with silica gel. The latter is filtered off and the filtrate is evaporated. The residue is dissolved in petroleumether. The solution is dried, filtered and evaporated, yielding 14.5 parts (92%) of 1-(2-bromo-1,1-dimethoxyethyl)-2,4-dichlorobenzene as a residue.

후처리

  1. temperatureThe reaction mixture is cooled
  2. washthe mixture is washed with 300 parts of water
  3. stirringThe organic phase is stirred with silica gel
  4. filtrationThe latter is filtered off
  5. customthe filtrate is evaporated
  6. dissolutionThe residue is dissolved in petroleumether
  7. customThe solution is dried
  8. filtrationfiltered
  9. customevaporated

출처 및 근거

ORD 기록
ord-5d9d3edc7f09408389e305292b92e9b5
출처 데이터셋
uspto-grants-1979_07
특허 번호
US04160838

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