Hydrochloric Acid → 6-Propionyl-3-methyl thiochromane

HRID 980502

반응식

HRID 980502 반응식
[Al+3].[Cl-].[Cl-].[Cl-].[C:5](Cl)(=[O:8])[CH2:6][CH3:7].[CH3:10][CH:11]1[CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[S:13][CH2:12]1.Cl>ClC=CCl>[C:5]([C:17]1[CH:18]=[C:19]2[C:14](=[CH:15][CH:16]=1)[S:13][CH2:12][CH:11]([CH3:10])[CH2:20]2)(=[O:8])[CH2:6][CH3:7]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 62324Propionyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 123085373-Methyl-thiochromane

생성물 1

HCID 545305286-Propionyl-3-methyl thiochromane

시약·촉매·용매 1

HCID 109001,2-Dichloroethylene용매

실험 절차

To 0.13M of AlCl3, 0.12M of propionyl chloride in 150 ml of 1,2-dichloroethylene, 0.1M (16.4 gr.) de 3-methyl-thiochromane are dropwise added at a temperature of ±5° C. After agitating the mixture for 3 hours at room temperature, a mixture of ice and HCl is added and extraction is made with CHCl3. The organic phase is dried on MgSO4, filtered and evaporated. 17.3 gr. of 6-propionyl-3-methyl thiochromane are so obtained, the homogeneity of which is verified by TLC and the structure of which is verified by NMR spectrum.

후처리

  1. additionis added
  2. extractionextraction
  3. customThe organic phase is dried on MgSO4
  4. filtrationfiltered
  5. customevaporated

출처 및 근거

ORD 기록
ord-8b058bd4b3774532b9045b91d321daa0
출처 데이터셋
uspto-grants-1987_01
특허 번호
US04638070

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