Hydrochloric Acid → HCID 20071772, 화합물

HRID 981252노트

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HRID 981252 반응식
[C:1]1([S:7][CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[O:9]=[C:10](Cl)[CH2:11][CH2:12][C:13](=[O:16])[O:14][CH3:15].[Cl-].[Al+3].[Cl-].[Cl-].Cl>ClC(Cl)C.ClCCl>[CH3:8][S:7][C:1]1[CH:6]=[CH:5][C:4]([C:10](=[O:9])[CH2:11][CH2:12][C:13]([O:14][CH3:15])=[O:16])=[CH:3][CH:2]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 7520ThioanisoleHCID 73888Butanoic acid, 4-chloro-4-oxo-, methyl esterHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 20071772HCID 20071772, 화합물

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 63651,1-Dichloroethane용매

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온도
0 °C

실험 절차

Thioanisole (12.4 g) and 1,4-dioxo-4-methoxybutyl chloride (16.5 g) in dichloroethane (100 ml) were cooled to 0° C. and aluminum chloride (16 g) was added, followed by another equivalent (16 g) and the reaction mixture was stirred at 0° C. for 2 hours. Ice was added, followed by 1N HCl. Dichloromethane (100 ml) was then added and the organic layer was separated, washed with water and then brine and dried with Na2SO4. Removal of the solvents yielded the title compound as an oil.

후처리

  1. additionIce was added
  2. customthe organic layer was separated
  3. washwashed with water
  4. dry with materialbrine and dried with Na2SO4
  5. customRemoval of the solvents

출처 및 근거

ORD 기록
ord-21ec6c9d41d84206a0858c3d8c29c91a
출처 데이터셋
uspto-grants-1991_02
특허 번호
US04990526

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