反应详情

A solution of 0.7 g of N-(12-hydroxydodecyl)-6-(1-piperazinyl)pyridine-3-carboxamide, 0.24 g of isopropyl bromide and 0.7 g of potassium carbonate in 20 ml of dimethylformamide was stirred at 100° C. for 3 hours. The reaction solution was diluted with chloroform, washed with water and a saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The residue thus obtained was chromatographed over a silica gel column to afford the title compound as a crystal.

1. washwashed with water
2. dry with materiala saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate
3. distillationThe solvent was distilled off under reduced pressure
4. customThe residue thus obtained
5. customwas chromatographed over a silica gel column