反应详情

To a suspension of 0.5 g of tert-butyl N-(12-hydroxydodecyl)carbamate in 15 ml of toluene were added 0.28 g of imidazole, 1.09 g of triphenylphosphine and 0.84 g of iodine and the mixture was stirred for 0.5 hour. Then, 5 ml of tetrahydrofuran was further added and the mixture was stirred for 2 hours. To the reaction solution was added ethyl acetate and the mixture was washed successively with a 10% aqueous solution of sodium thiosulfate and water and dried over anhydrous sodium sulfate and the solvent was distilled off under reduced pressure. The residue thus obtained was chromatographed over a silica gel column to afford 0.42 g of the title compound.

1. stirringthe mixture was stirred for 2 hours
2. washthe mixture was washed successively with a 10% aqueous solution of sodium thiosulfate and water
3. dry with materialdried over anhydrous sodium sulfate
4. distillationthe solvent was distilled off under reduced pressure
5. customThe residue thus obtained
6. customwas chromatographed over a silica gel column