Hydrochloric Acid → 8-Methyl-4-ethoxy-1,1-dioxothiochroman-7-carboxylic acid

HRID 1005295Notes

Reaction equation

[CH2:1](NO)[CH3:2].C(=O)([O-])[O-:6].[K+].[K+].[CH3:11][C:12]1[C:13]([C:23]([OH:25])=[O:24])=[CH:14][CH:15]=[C:16]2[C:21]=1[S:20][CH2:19][CH2:18][C:17]2=[O:22].Cl.[OH2:27]>CO>[CH3:11][C:12]1[C:13]([C:23]([OH:25])=[O:24])=[CH:14][CH:15]=[C:16]2[C:21]=1[S:20](=[O:6])(=[O:27])[CH2:19][CH2:18][CH:17]2[O:22][CH2:1][CH3:2]

Participants

Conditions

Temperature: 20 °C

Procedure

0.88 g (9 mmol) of ethylhydroxylamine is initially introduced in 20 ml of methanol. 0.62 g (4.5 mmol) of potassium carbonate is then added, followed by 2.0 g (9 mmol) of 8-methylthiochroman-4-one-7-carboxylic acid. The reaction is stirred at about 20° C. for 10 days. It is worked up by addition of water and 2N hydrochloric acid, and the resulting precipitate is filtered of f with suction and dried.

Workup

filtrationthe resulting precipitate is filtered of f with suction
customdried

Sources & evidence

ORD record: ord-1ccb663a67bf4114ac43f898f8f9f1b6
Source dataset: uspto-grants-2000_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06054414

Reaction notes

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