反应详情

温度

100 °C

To a solution of 0.96 g of 2,3-dichloro-6-trifluoromethylbenzonitrile in 7 ml of N,N-dimethylformamide was added 0.46 g of spray-dried potassium fluoride and 0.1 g of 18-crown-6-ether and the mixture was stirred for 6 hours at 100° C. under a nitrogen atmosphere. After cooling, the reaction mixture was poured into ice water and extracted with ethyl acetate. The organic layer was washed with saturated saline solution and dried over anhydrous magnesium sulfate. After distilling the solvent under reduced pressure, the crude product obtained was purified by using silica gel column chromatography to obtain 0.65 g of the title compound(mp. 43-44° C.).

1. temperatureAfter cooling
2. extractionextracted with ethyl acetate
3. washThe organic layer was washed with saturated saline solution
4. dry with materialdried over anhydrous magnesium sulfate
5. distillationAfter distilling the solvent under reduced pressure
6. customthe crude product obtained
7. customwas purified