HRID1006519

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7175

Propylparaben

C10H12O3

HCID7456

Methylparaben

C8H8O3

结构：CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.Cc1c(Nc2ncccc2C(=O)O)cccc1C(F)(F)F

HCID39212

未命名化合物

结构：CS(=O)(=O)c1ccc([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)cc1

HCID114811

Florfenicol

C12H14Cl2FNO4S

PRODUCTS

生成物

结构：CS(=O)(=O)c1ccc([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)cc1.Cc1c(Nc2ncccc2C(=O)O)cccc1C(F)(F)F

HCID86602307

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

溶剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

PROCEDURE

实验过程

The NMP and a portion of the polyethylene glycol 200 are charged to the compounding vessel. Florfenicol, methyl p-hydroxybenzoate and propyl p-hydroxybenzoate are added to the vessel and mixed until dissolved. Water is added, followed by the flunixin meglumine, and mixed until solids are dissolved. Q.S. to final volume with polyethylene glycol 200 if needed.

WORKUP

后处理

additionmixed
dissolutionuntil dissolved
additionmixed until solids
dissolutionare dissolved

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b616607b6b004c16841480c6e69606f6
来源数据集: uspto-grants-2004_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06790867B2
来源说明: uspto-grants-2004_09

反应 SMILES

[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([C@@H:11]([OH:21])[C@H:12]([NH:15][C:16]([CH:18]([Cl:20])[Cl:19])=[O:17])[CH2:13][F:14])=[CH:9][CH:10]=1)(=[O:4])=[O:3].COC(C1C=CC(O)=CC=1)=O.OC1C=CC(C(OCCC)=O)=CC=1.[CH3:46][C:47]1[C:52]([NH:53][C:54]2[N:59]=[CH:58][CH:57]=[CH:56][C:55]=2[C:60]([OH:62])=[O:61])=[CH:51][CH:50]=[CH:49][C:48]=1[C:63]([F:66])([F:65])[F:64].CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>O.CN1C(=O)CCC1>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([C@@H:11]([OH:21])[C@H:12]([NH:15][C:16]([CH:18]([Cl:20])[Cl:19])=[O:17])[CH2:13][F:14])=[CH:9][CH:10]=1)(=[O:4])=[O:3].[CH3:46][C:47]1[C:52]([NH:53][C:54]2[N:59]=[CH:58][CH:57]=[CH:56][C:55]=2[C:60]([OH:62])=[O:61])=[CH:51][CH:50]=[CH:49][C:48]=1[C:63]([F:65])([F:64])[F:66]