Hydrochloric Acid → 3-(3-Chloropyrazinyl)-1-azabicyclo[2.2.2]octan-3-ol

HRID 100656Notes

Reaction equation

HRID 100656 reaction equation
[CH2:33]1[O:34][CH2:35][CH2:36][CH2:37]1.[CH3:1][C:2]1([CH3:3])[CH2:4][CH2:5][CH2:6][C:7]([CH3:8])([CH3:9])[NH:10]1.[CH3:38][CH2:39][CH2:40][CH2:41][CH2:42][CH3:43].[CH3:44][CH2:45][OH:46].[Cl:16][c:17]1[n:18][cH:19][cH:20][n:21][cH:22]1.[ClH:32].[Li:11][CH2:12][CH2:13][CH2:14][CH3:15].[N:23]12[CH2:24][C:25](=[O:31])[CH:26]([CH2:27][CH2:28]1)[CH2:29][CH2:30]2>>[Cl:16][c:17]1[n:18][cH:19][cH:20][n:21][c:22]1[C:25]1([OH:31])[CH2:24][N:23]2[CH2:28][CH2:27][CH:26]1[CH2:29][CH2:30]2

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 702EthanolHCID 8028TetrahydrofuranHCID 8058HexaneHCID 130352,2,6,6-TetramethylpiperidineHCID 195073-QuinuclidinoneHCID 73277ChloropyrazineHCID 178418339Butyllithium

Product 1

HCID 103318403-(3-Chloropyrazinyl)-1-azabicyclo[2.2.2]octan-3-ol

Sources & evidence

ORD record
ord-8b14cf0cfa48413b8783d81a415ae02f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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