反应详情

温度

150 °C

3-amino-4-(benzylamino)quinoline (9.5 g; 0.038 mol) and glycolic acid (6.8 g; 0.089 mol) were mixed and the mixture was heated at 150° C. for about 4 hr. The dark mixture was then dissolved in dilute hydrochloric acid with heating. Upon cooling a precipitate formed and was filtered from the mixture. The solid was dissolved in hot water. The solution was then made basic with ammonium hydroxide to precipitate the product. A second, less pure, small crop was obtained from the original filtrate by making it basic with ammonium hydroxide. The solid was triturated in ethyl acetate to give a green colored powder. Total yield was 82%. The product was recrystallized from methanol to give a pure sample m.p. 211-213° C. Analysis: Calculated: C, 74.7; H, 5.2; N, 14.5. Found: C, 74.4; H, 5.1; N, 14.4.

1. temperaturewith heating
2. temperatureUpon cooling
3. customa precipitate formed
4. filtrationwas filtered from the mixture
5. dissolutionThe solid was dissolved in hot water
6. customto precipitate the product
7. customA second, less pure, small crop was obtained from the original filtrate
8. customThe solid was triturated in ethyl acetate
9. customto give a green colored powder
10. customThe product was recrystallized from methanol
11. customto give a pure sample m.p. 211-213° C