反应详情

1-Chloro-7-methoxy-3-(2-methoxyphenyl)isoquinoline (0.56 g) was reacted with N-ethylpiperazine (5 ml) and potassium carbonate (0.5 g) at 120° C. for 5 hr. To the resulting reaction solution were added ethyl acetate and water, and then it was extracted with ethyl acetate. The resulting organic layer was washed with water and brine, and dried over magnesium sulfate. The solvent was evaporated, and the resulting residue was purified by silica gel column chromatography (methylene chloride/methanol system), to give 0.43 g of the free compound of the title compound as a pale yellow oil.

1. customTo the resulting reaction solution
2. extractionit was extracted with ethyl acetate
3. washThe resulting organic layer was washed with water and brine
4. dry with materialdried over magnesium sulfate
5. customThe solvent was evaporated
6. customthe resulting residue was purified by silica gel column chromatography (methylene chloride/methanol system)