反应详情

3-Amino-1-bromoisoquinoline (10.3 g) and 1-ethylpiperazine (10.5 g) were reacted in the presence of potassium carbonate (13.8 g) in N,N-dimethylformamide (80 ml) at room temperature for 3 days. The reaction solution was concentrated, followed by the addition of purified water (500 ml), and the resulting mixture was stirred under ice-cooling for 1 hr. The resulting ocherous precipitates were collected by filtration, washed with a small amount of ice-water and hexane, and then dried at 50° C. under reduced pressure, to give 3-amino-1-(4-ethylpiperazin-1-yl)isoquinoline (4.5 g).

1. concentrationThe reaction solution was concentrated
2. additionfollowed by the addition of purified water (500 ml)
3. temperaturecooling for 1 hr
4. customThe resulting ocherous precipitates
5. filtrationwere collected by filtration
6. washwashed with a small amount of ice-water and hexane
7. customdried at 50° C. under reduced pressure