Dimethylamine, hydrochloride → HCID 22668601, compound

HRID 1007392Notes

Reaction equation

HRID 1007392 reaction equation
[C:1]([CH2:4][N:5]([S:15]([CH3:18])(=[O:17])=[O:16])[C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=1)([OH:3])=O.Cl.[CH3:20][NH:21][CH3:22].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C1C=CC2N(O)N=NC=2C=1.C(N(C(C)C)C(C)C)C>CN(C)C=O.O>[CH3:20][N:21]([CH3:22])[C:1]([CH2:4][N:5]([S:15]([CH3:18])(=[O:17])=[O:16])[C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=1)=[O:3]

Participants

8

Reactant 5

HCID 10473Dimethylamine, hydrochlorideHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 22668634HCID 22668634, compound

Product 1

HCID 22668601HCID 22668601, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

7.0 g of N-carboxymethyl-N-methylsulphonyl-4-nitroaniline, 2.5 g of dimethylamine hydrochloride, 8.1 g of TBTU and 3.9 g of HOBT are dissolved in 125 ml of dimethylformamide and at 0° C. 17.6 ml of N-ethyl-diisopropylamine are added. The mixture is stirred for 4 hours at ambient temperature, diluted with 1 l water and the precipitate formed is suction filtered. After washing with water, ethanol and ether the residue is dried at 70° C. in vacuo.

Workup

  1. customthe precipitate formed
  2. filtrationfiltered
  3. washAfter washing with water, ethanol and ether the residue
  4. customis dried at 70° C. in vacuo

Sources & evidence

ORD record
ord-a032b996cf8b459ca6bf3e2f0717fb5d
Source dataset
uspto-grants-2004_09
Patent number
US06794395B1

Reaction notes

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