反应详情

2,6-Difluoropyridine (25 g), isopropyl alcohol (100 ml) and hydrazine hydrate (40 ml) were mixed and refluxed with heating for 3 hours. The isopropyl alcohol was evaporated under reduced pressure, and the residue was added with water. The deposited crystals were collected by filtration, washed with water and dried to obtain 6-fluoro-2-hydrazinopyridine (21.2 g, yield: 76.8%). Coloration was observed during drying, and accordingly, the product was used for the next reaction immediately after the drying.

1. temperaturerefluxed
2. temperaturewith heating for 3 hours
3. customThe isopropyl alcohol was evaporated under reduced pressure
4. additionthe residue was added with water
5. filtrationThe deposited crystals were collected by filtration
6. washwashed with water
7. customdried