Hydrochloric Acid → HCID 22666324, compound

HRID 1007919Notes

Reaction equation

HRID 1007919 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[C:7]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][N:15]([CH:17]3[CH2:19][CH2:18]3)[CH3:16])[CH:8]=[CH:9][C:2]1=2.[ClH:20]>C(OCC)(=O)C.C(OC(C)C)(C)C>[ClH:20].[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[C:7]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][N:15]([CH:17]3[CH2:19][CH2:18]3)[CH3:16])[CH:8]=[CH:9][C:2]1=2

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22666277HCID 22666277, compound

Product 1

HCID 22666324HCID 22666324, compound

Reagents, catalysts & solvents 2

HCID 7914Diisopropyl EtherSolventHCID 8857Ethyl AcetateSolvent2×

Procedure

In 2.2 mL of ethyl acetate is dissolved 0.44 g of N-[2-(2-benzo[b]thiophen-5-ylethoxy)ethyl]-N-cyclopropyl-N-methylamine, to which is added 0.60 mL of 3.5 mol/L solution of dry hydrogen chloride in ethyl acetate. The resulting mixture is stirred at ambient temperature for one hour. The reaction mixture is diluted with 5 mL of diisopropyl ether and stirred at ambient temperature for one hour. The deposited crystal is collected by filtration, washed with ethyl acetate and dried to obtain 0.31 g of N-[2-(2-benzo[b]thiophen-5-ylethoxy)ethyl]-N-cyclopropyl-N-methylamine hydrochloride.

Workup

  1. stirringstirred at ambient temperature for one hour
  2. filtrationThe deposited crystal is collected by filtration
  3. washwashed with ethyl acetate
  4. customdried

Sources & evidence

ORD record
ord-5544f50bd32b46a18f5d96d59b5996ff
Source dataset
uspto-grants-2004_09
Patent number
US06797726B1

Reaction notes

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