Hydrochloric Acid → HCID 22666508, compound

HRID 1007923Notes

Reaction equation

HRID 1007923 reaction equation
[C:1]([O:7][CH2:8][CH2:9][N:10]([CH2:12][CH2:13][O:14][CH2:15][CH2:16][C:17]1[CH:25]=[CH:24][C:20]2[S:21][CH:22]=[CH:23][C:19]=2[CH:18]=1)[CH3:11])(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].[ClH:26]>C(OCC)(=O)C.C(OC(C)C)(C)C>[ClH:26].[C:1]([O:7][CH2:8][CH2:9][N:10]([CH2:12][CH2:13][O:14][CH2:15][CH2:16][C:17]1[CH:25]=[CH:24][C:20]2[S:21][CH:22]=[CH:23][C:19]=2[CH:18]=1)[CH3:11])(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22666292HCID 22666292, compound

Product 1

HCID 22666508HCID 22666508, compound

Reagents, catalysts & solvents 2

HCID 7914Diisopropyl EtherSolventHCID 8857Ethyl AcetateSolvent2×

Procedure

In 3.2 mL of ethyl acetate is dissolved 0.54 g of 2-{[2-(2-benzo[b]thiophen-5-ylethoxy)ethyl]-(methyl)amino}ethyl pivalate, to which is added 0.53 ml of 3.6 mol/L solution of dry hydrogen chloride in ethyl acetate. The mixture is stirred at ambient temperature for one hour. The reaction mixture is diluted with 5 mL of diisopropyl ether and stirred at ambient temperature for one hour. The deposited crystal is collected by filtration, washed with ethyl acetate and dried to obtain 0.46 g of 2-{[2-(2-benzo[b]thiophen-5-ylethoxy)ethyl](methyl)amino}ethyl pivalate hydrochloride.

Workup

  1. stirringstirred at ambient temperature for one hour
  2. filtrationThe deposited crystal is collected by filtration
  3. washwashed with ethyl acetate
  4. customdried

Sources & evidence

ORD record
ord-177d8b83c26f49d88df6f6f0e267ea31
Source dataset
uspto-grants-2004_09
Patent number
US06797726B1

Reaction notes

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