Tetrahydrofuran → 3-Hydroxypyrrolidine-1-carbonyl Chloride

HRID 100891Notes

Reaction equation

HRID 100891 reaction equation
[CH2:28]1[O:29][CH2:30][CH2:31][CH2:32]1.[CH:7]([N:8]([CH2:9][CH3:10])[CH:11]([CH3:12])[CH3:13])([CH3:14])[CH3:15].[Cl:16][C:17]([Cl:18])([O:19][C:20](=[O:21])[O:22][C:23]([Cl:24])([Cl:25])[Cl:26])[Cl:27].[NH:1]1[CH2:2][CH:3]([OH:6])[CH2:4][CH2:5]1>>[N:1]1([C:17]([Cl:16])=[O:19])[CH2:2][CH:3]([OH:6])[CH2:4][CH2:5]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 81531DiisopropylethylamineHCID 94429TriphosgeneHCID 982104-Hydroxypyrrolidine

Product 1

HCID 866300603-Hydroxypyrrolidine-1-carbonyl Chloride

Sources & evidence

ORD record
ord-6a7160eda12142398c52bd9508e11ee0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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