反应详情

A solution containing 6,8-dibromo-chroman-4(S)-ol in tetrahydrofuran (0.17M) and 1.2 equivalents of diphenylphosphorylazide was stirred for 15 minutes at room temperature. The solution was cooled to 10° C. and 2.5 equivalents of 1,8-diazabicyclo[5.4.0]undec-7-ene added. The mixture was stirred with gradual warming to room temperature and maintained for 48 h. The mixture was diluted with ethylacetate and washed with brine followed by water. The organic phase was concentrated to afford the title compound as a tan oil.

1. temperatureThe solution was cooled to 10° C.
2. stirringThe mixture was stirred
3. temperaturewith gradual warming to room temperature
4. temperaturemaintained for 48 h
5. washwashed with brine
6. concentrationThe organic phase was concentrated